Eating in Sync with Biological Clock Could Replace Problematic Diabetes Treatment

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By : dLife Editors

A small study from Tel Aviv University finds that a starch-rich breakfast consumed early in the morning coupled with a small dinner could replace insulin injections and other diabetes medications for many people with diabetes.

The researchers say this finding could help many with Type 2 diabetes who are dependant on insulin injections that are linked to weight gain. This, according to scientists triggers a vicious cycle of higher insulin doses, continuous weight gain, a higher incidence of cardiovascular disease and other complications.

“The traditional diabetic diet specifies six small meals spread throughout the day,” explains Professor Daniela Jakubowicz of TAU’s Sackler Faculty of Medicine and Wolfson Medical Center’s Diabetes Unit.   “But our research proposes shifting the starch-rich calories to the early hours of the day. This produces a glucose balance and improved glycemic control among Type 2 diabetics.”

Jakubowicz says her team believes that through this regimen it will be possible for diabetics to significantly reduce or even stop the injections of insulin, and most of the antidiabetic medications, to achieve excellent control of glucose levels.

According to the new research, our metabolism and biological clock are optimized for eating in the morning and for fasting during the evening and night, when we are supposed to be asleep.

“But the usual diet recommended for Type 2 diabetes consists of several small meals evenly distributed throughout the day — for example, three meals and three snacks daily, including a snack before going to sleep to prevent a drop in sugar levels during the night,” Prof. Jakubowicz says.

“But the ‘6M-diet,’ as this is called, has not been effective for sugar control, so diabetics require additional medication and insulin. And insulin injections lead to weight gain, which further increases blood sugar levels,” Prof. Jakubowicz adds.

How was the Study Conducted?

The researchers studied 29 participants with Type 2 diabetes and compared a new “3M-diet,” more in alignment with the human biological clock. The control group was on the traditional 6M-diet.

The experimental 3M-diet comprised a meal of bread, fruits, and sweets in the early hours of the morning; a substantial lunch; and a small dinner specifically lacking starches, sweets, and fruits.

The group on the traditional 6M-diet did not lose weight and did not experience any improvement of sugar levels, requiring an increase in medication and insulin doses. But the group on the 3M-diet not only lost weight but also experienced substantially improved sugar levels.

“Their need for diabetic medication, especially for insulin doses, dipped substantially. Some were even able to stop using insulin altogether,” adds Prof. Jakubowicz. “In addition, the 3M-diet improved the expression of biological clock genes. This suggests the 3M-diet is not only more effective in controlling diabetes. It may also prevent many other complications such as cardiovascular disease, aging, and cancer, which are all regulated by the biological clock genes.”

The upregulation of the biological clock gene expression in the 3M-diet might be the mechanism behind its success, as it enhances insulin secretion and improves sugar delivery into the muscles, creating a balanced daytime and nocturnal glucose metabolism.

The researchers are now investigating the role certain proteins play in breakfast foods consumed by diabetics.

The research has been published in Diabetes Care.


  1. American Friends of Tel Aviv University. (2019, Dec. 3). Eating in sync with the biological clock could replace problematic diabetes treatment. EurekAlert! Retrieved Dec. 3, 2019, from